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Background—Patients with primary pulmonary hypertension (PPH) have a pulmonary vasculopathy that leads to exercise intolerance due to dyspnea and fatigue. To better understand the basis of the exercise limitation in patients with PPH, cardiopulmonary exercise testing (CPET) with gas exchange measurements, New York... 顯示更多 Background—Patients with primary pulmonary hypertension (PPH) have a pulmonary vasculopathy that leads to exercise
intolerance due to dyspnea and fatigue. To better understand the basis of the exercise limitation in patients with PPH,
cardiopulmonary exercise testing (CPET) with gas exchange measurements, New York Heart Association (NYHA)
symptom class, and resting pulmonary hemodynamics were studied.
Methods and Results—We retrospectively evaluated 53 PPH patients who had right heart catheterization and cycle
ergometer CPET studies to maximum tolerance as part of their clinical workups. No adverse events occurred during
CPET. Reductions in peak O2 uptake (V˙ O2), anaerobic threshold, peak O2 pulse, rate of increase in V˙ O2, and ventilatory
efficiency were consistently found. NYHA class correlated well with the above parameters of aerobic function and
ventilatory efficiency but less well with resting pulmonary hemodynamics.
Conclusions—Patients with PPH can safely undergo noninvasive cycle ergometer CPET to their maximal tolerance. The
CPET abnormalities were consistent and characteristic and correlated well with NYHA class.
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