protease和proteinase的差異？（贈10點）

Question

蛋白酶的英文protease和proteinase都有人用，

請問，這兩個字有何差異？

已更新項目:

Usually, Wikipedia is a quiet useful tool.

However, I hope to get a professional answer.

2 個已更新項目:

To cssnoopy,

Thanks very much for providing me these opinion.

What I said I want to get a professional answer did have malice.

In fact, I thought "protease" and "proteinase" have the same meaning.

3 個已更新項目:

However, in a class, a National Chair Professor of biochemistry said the two terms are different, so I asked this question.

There is one opinion that could be searched on the web.

Although I am not really sure if it is correct or not.

4 個已更新項目:

It says, peptidase can be devided into exo-peptidase and endo-peptidase.

And of these three terms (peptidase, exo-peptidase and endo-peptidase), peptidase could be named protease, endo-peptidase could be called proteinase and exo-peptidase could be called amino-peptidase.

5 個已更新項目:

I wonder do you have any idea on this opinion.

6 個已更新項目:

所以 成成 大大 認為以上說法是可信的嗎？

Answer 1

最佳解答

protease = proteolytic enzyme

會分解蛋白質的酵素

例如 protease 功能6大類 (依IUBNB 分類)

oxidoreductases transferases hydrolases lyases isomerases ligases

proteinase = protein kinase

使蛋白質磷酸化的酵素 可以活化蛋白質 使蛋白質發揮功用

例如 protein kinase A (PKA)

2006-08-01 02:47:04 補充：

哈哈 sorry 講錯了protease = proteinase 通稱而已 沒有什麼差

2006-08-03 14:31:45 補充：

講的很清楚 thanks. 我翻了molecular biology (Lodish)裡頭也沒說.

2006-08-05 04:07:57 補充：

Biochem J. 1986 August 1; 237(3): 935. http://delphi.phys.univ-tours.fr/Prolysis/intropro... 包含endopeptidase and exopeptidase然後proteinase = endopeptidase然後protease = peptidase (總稱)邏輯推論下 若protease = proteinase則此protease 的作用為endopeptidase 人家老早就搞定了

Answer 2

http://www.pubmedcentral.nih.gov/pagerender.fcgi?a...

Answer 3

Proteases, proteinases, and peptidases are all the same. I think they were just named differently when initially members of this class of enzymes were discovered independently and named separately, until later realizing that they follow a set pattern of enzymatic activities and are actually similar.

See this excerpt from wikipedia:

Proteases (proteinases, peptidases or proteolytic enzymes) are enzymes that break peptide bonds between amino acids of proteins. The process is called proteolytic cleavage, a common mechanism of activation or inactivation of enzymes especially involved in blood coagulation or digestion. They use a molecule of water for this and are thus classified as hydrolases.

http://en.wikipedia.org/wiki/Proteinase

2006-08-02 11:43:13 補充：

Sure, if you want PROFESSIONAL ANSWERS:read:Baig S, et al. Cysteine proteinase inhibitors in murine cysticercosis. Antimicrob Agents Chemother. 2006 Aug;50(8):2886-8.you would find that the authors used proteinase and protease interchangeably.

2006-08-02 11:44:36 補充：

Then read:Dolezal P, Likic V, Tachezy J, Lithgow T. Evolution of the molecular machines for protein import into mitochondria. Science. 2006 Jul 21;313(5785):314-8.You would find that authors used protease and peptidase in describing the same protein.I hope this is PROFESSIONAL enough.

參考資料： I am a grad student in biology~!