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匿名使用者 發問時間: 社會與文化語言 · 1 0 年前

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Higher umbilical cord blood STB levels20,21 or increased STB values on the first day of life2,23 have been shown in previous studies of G-6-PD-deficient neonates, suggesting either in utero or a very early postnatal onset of jaundice. However, as there was no attempt at correlation between this early bilirubinemia and subsequent jaundice in these studies, it cannot be concluded that the former was the forerunner of hyperbilirubinemia. Our demonstration of a significant correlation between very early STB values and later bilirubin values and the significantly higher relative risk of first STB result greater than or equal to the mean in the subsequent development of hyperbilirubinemia now demonstrates that this perinatal bilirubinemia is the precursor of subsequent jaundice and hyperbilirubinemia.

Although umbilical cord blood sampling undoubtedly would have offered a more accurate representation of the in utero status, for logistical reasons and because of difficulties in coordinating the study with the delivery room staff, we chose to obtain samples from the infants within 3 hours of delivery to reflect the in utero situation. Although we cannot exclude categorically a very early postnatal onset of the bilirubinemia, we are confident that this method of sampling reliably reflected the in utero state. Presuming that the hourly rates of rise during the first days of life reflected the rise during the first 3 hours of life as well, the first STB values should have been only marginally elevated over the actual cord blood values and should not have affected the comparisons between the study and control groups to any major degree.

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  • neka
    Lv 6
    1 0 年前
    最佳解答

    更高的umb ilical 繩子血STB levels20,21或者增加的STB價值在life2,23的第一天已經被在G 6 PD 缺乏新生嬰兒的以前的研究過程中顯示, 或者在子宮裡或者在一次黃膽病的非常盡快的初生嬰兒的進攻裡建議。 但是, 因為在這些研究過程中,在這早期的bilirubinemia 和隨后的黃膽病之間,在相互關係有不曾試圖,前者是hyperbilirubinemia的先驅,這不能被結束。 我們的一個標誌的遊行示威 在盡快STB之間的相互關係ificant 估價和更晚bilirubin 估價和那些更相當高有關危險的大的第一個結果STB的比或者等于那些隨后發展的hyperbilirubinemia的那些平均值現下證明 雖然臍帶血 取樣無疑可能提供時髦的子宮地位的更準確的表現, 由於邏輯原因和因為在與交付房間人員協調研究過程中的困難, 我們選擇在交付3個小時內從那些嬰兒那裡獲得樣品反映出時髦的子宮情勢。 雖然我們不能無條件排除一次bilirubinemia的非常盡快的初生嬰兒的進攻,但是我們自信取樣可靠反映出的時髦的子宮國家的這種方法。 ise在生活的第一天也在生活的前3個小時期間反映出升高, 價值應該只稍微越過真實繩子血提升的第一個STB 估價並且不影響比較在研究和對照組與任何主要學位之間。

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