士豪 發問時間: 健康其他:保健 · 1 0 年前

hydroxychloroquine副作用~~

hydroxychloroquine用來治療早期風濕性關節炎...請問有相關文章是說明此藥對皮膚的副作用嗎??

我在醫院藥袋上看到對皮膚會有變成藍色的副作用= =

請回答者能附上參考資料..最好是國內外都認可的資料>\"<謝謝

3 個解答

評分
  • 匿名使用者
    1 0 年前
    最佳解答

    類風濕性關節炎的葯物治療:疾病緩解葯物(Disease Modifying Anti-Rheumatic Drugs,也稱免疫調節劑):抗瘧疾葯物---奎寧類(Hydroxychloroquine,氯奎寧Chloroquine) 這類葯物也有相當的緩解作用,但約二到三個月的治療才看得出療效。目前較常使用的葯物為Hydroxychloroquine(商品名Plaquenil)。以前使用的chloroquine抗瘧疾葯物可能產生副作用,如噁心、嘔吐、禿髮、血球數目減少、畏光視覺障礙及皮膚色素沈著等。而新一代改良型hydroxychloroquine的使用,很少見上述副作用,可以說是相當安全的葯物。但使用期間仍應注意有無視力變化的情形出現,並每年定期到眼科檢查一次視網膜是否有病變。http://www.google.com.tw/search?hl=zh-TW&q=hydroxy... Cellcept (MMF, 山喜多)、細胞激素拮抗劑治療、類荷爾蒙拮抗劑治療 DHEA、基因治療以及幹細胞移植等。http://www.tcmed.org.tw/asp/Publication_v.asp?peri...

    參考資料: 如文
  • 6 年前

    到下面的網址看看吧

    ▶▶http://qoozoo201409150.pixnet.net/blog

  • Yy
    Lv 7
    1 0 年前

    hydroxychloroquine具免疫調節作用 屬disease-modifying antirheumatic drugs 改善症狀用 減少抗發炎止痛藥及類固醇用量 其最令人擔心的副作用是長期服用使視力減退

    David J. Browning, Hydroxychloroquine and chloroquine retinopathy: screening for drug toxicity. American Journal of Ophthalmology, 133(5) 649-656 (2002)

    2006-08-19 15:33:17 補充:

    hydroxychloroquine is not associated with renal, hepatic, or bone marrow toxicity in patients with RA. However, patients may discontinue the drug because of the most frequent gastrointestinal adverse effects (nausea, vomiting, and abdominal pain).

    2006-08-19 15:33:53 補充:

    Other side effects reported are rash, vertigo, headache and insomnia. The principal ocular adverse effect of HCQ is a progressive retinopathy involving color vision changes.

    2006-08-19 15:34:11 補充:

    This retinopathy

    has been noted to occur without early warning signs and, therefore, ophthalmologic examinations are mandatory before therapy is started and every 4 to 6 months thereafter.

    2006-08-19 15:34:17 補充:

    The high loading dosage of HCQ (800-1200 mg/d) has not been associated with greater ocular toxicity than the conventional dosage(400 mg/d) commonly used in RA. Furthermore, the new dosage regimen for HCQ (up to 1200 mg/d for 6 weeks) is well tolerated, except for the gastrointestinal adverse events.

    2006-08-19 15:36:38 補充:

    Ehab S. El Desoky, Pharmacotherapy of rheumatoid arthritis: an overview. Current Therapeutic Research, Volume 62, Issue 2, February 2001, Pages 92-112

    2006-08-19 16:04:22 補充:

    hydroxychloroquine引致的皮膚副作用主要是其光敏感性photo-sensitive 所以少曬太陽

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