Pawn 發問時間: 社會與文化語言 · 1 0 年前

可以幫我翻譯Status epilepticus嗎?

Reports that the combination of phenobarbitone and a benzodiazepine can lead to cardiorespiratory compromise, along with concerns about its hypotensive and respiratory depressant effect, mean that phenobarbitone is used less commonly as a first line treatment. These opinions are not supported by randomised controlled trials, which suggest that side effects with phenobarbitone are no greater than with other regimens.16

Evidence

Two randomised studies compared phenobarbitone with diazepam against lorazepam, phenytoin alone, or diazepam and phenytoin.15 16 These studies established that phenobarbitone is as efficacious as other regimens tested and does not result in significantly greater side effects.

Dose

Intravenous phenobarbitone should be given at 10-20 mg/kg at 100 mg/minute.

Refractory status epilepticus

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Refractory status epilepticus

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References

If the status epilepticus continues despite a benzodiazepine and an adequate loading dose of phenytoin, further management should take place on the intensive care unit, with anaesthesia to control the epileptic activity. In addition to anaesthesia, antiepileptic drug treatment should continue. You should monitor the patient with an electroencephalograph at least once a day.

Anaesthesia can be induced by barbiturate or non-barbiturate drugs. Several anaesthetics have been recommended; the most commonly used anaesthetics are the intravenous barbiturates thiopentone and pentobarbitone, the intravenous non-barbiturate propofol, and continuous midazolam infusion.24 25

2 個解答

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  • 匿名使用者
    1 0 年前
    最佳解答

    報告顯示phenobarbitone(苯巴比妥)及benzodiazepine(苯重氮基鹽)的組合可能引致心肺受損,加上它有抗高血壓及抑制呼吸的效果,使phenobarbitone較少用於第一線治療。但隨機對照試驗結果並不支援這個觀點,它顯示phenobarbitone的副作用並不比其他藥物大.16

    證據

    兩個隨機研究比較phenobarbitone加diazepam(苯甲二氮 - NE12D -一種鎮靜安眠藥)及單獨使用lorazepam(蘿拉西泮), phenytoin (苯妥英),或diazepamy與phenytoin共用的作用.15 16 這些研究顯示 phenobarbitone 相對於其他測試的藥物,並無明顯較大的副作用.

    劑量

    靜脈注射phenobarbitone 劑量應為每公斤10-20 毫克,每分鐘100毫克。

    難以治療的癲癇持續狀態

    導言

    誰會患上?

    我怎麼診斷..

    我如果治療...

    難以治療的癲癇持續狀態

    我應何時轉介(??)

    前景如何?

    參考

    如果使用了benzodiazepine及足夠負荷劑量的phenytoin,但癲癇持續狀態一直繼續,須送到深切治療部,以麻醉的方式,控制癲癇的狀況.除麻醉外,亦應繼續使用鎮癇劑.你應最少每天一次用腦電圖監測病人的狀況.麻醉可用巴比妥(barbiturate)或非巴比妥(non-barbiturate)藥物作誘.有多種麻醉劑被推薦使用;最常用的麻醉劑是靜脈注射barbiturates thiopentone (硫噴妥鈉巴比妥)及and pentobarbitone(戊巴比妥),靜脈注射非巴比妥propofol(丙泊酚),及連續輸注midazolam(咪達唑侖)24 25

  • 1 0 年前

    5 points for a hard work?? dude, you are really stingy, do you know that?

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