用酵母菌做基因複製的報告怎麼做捏!

我需要新一點的資料,最好是2005年以後的,不過之前的資料也可以接受,請大家幫我解圍吧!

題目以Gene Complexity and Gene Duplicability 為主!

3Q囉~~~

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    Gene complexity and gene duplicability.

    Curr Biol. 2005; 15(11):1016-21 (ISSN: 0960-9822)

    He X ; Zhang J

    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor 48109, USA.

    Eukaryotic genes are on average more complex than prokaryotic genes in terms of expression regulation, protein length, and protein-domain structure [1-5]. Eukaryotes are also known to have a higher rate of gene duplication than prokaryotes do [6, 7]. Because gene duplication is the primary source of new genes [], the average gene complexity in a genome may have been increased by gene duplication if complex genes are preferentially duplicated. Here, we test this "gene complexity and gene duplicability" hypothesis with yeast genomic data. We show that, on average, duplicate genes from either whole-genome or individual-gene duplication have longer protein sequences, more functional domains, and more cis-regulatory motifs than singleton genes. This phenomenon is not a by-product of previously known mechanisms, such as protein function [10-13], evolutionary rate [14, 15], dosage [11], and dosage balance [16], that influence gene duplicability. Rather, it appears to have resulted from the sub-neo-functionalization process in duplicate-gene evolution [11]. Under this process, complex genes are more likely to be retained after duplication because they are prone to subfunctionalization, and gene complexity is regained via subsequent neofunctionalization. Thus, gene duplication increases both gene number and gene complexity, two important factors in the origin of genomic and organismal complexity.

    2006-12-22 15:54:10 補充:

    Rather, it appears to have resulted from the sub-neo-functionalization process in duplicate-gene evolution [11].

    2006-12-22 15:54:30 補充:

    , and gene complexity is regained via subsequent neofunctionalization. Thus, gene duplication increases both gene number and gene complexity, two important factors in the origin of genomic and organismal complexity.

    2006-12-22 15:54:43 補充:

    基因複雜和基因duplicability 。

    Curr Biol 。 2005 年; 15(11):1016-21 (ISSN: 0960-9822)

    他 X; 張 J

    生態的部門和演變生物, 密執安大學, 安阿伯48109, 美國。

    Eukaryotic 基因比prokaryotic 基因是平均複雜根據表示章程、蛋白質長度, 和蛋白質領域結構[ 1-5 ] 。真核比prokaryotes 並且知道有基因複製的一種更高的速率[ 6, 7 ] 。

    2006-12-22 15:55:10 補充:

    由於基因複製是新基因的主要來源[ ], 平均基因複雜在染色體也許被基因複製增加了如果複雜基因優先地被複製。這裡, 我們測試這個"基因複雜和基因duplicability" 假說以酵母genomic 資料。我們表示, 平均, 複製基因從或完全染色體或單獨基因複製有更長的蛋白質序列、更加功能的領域, 和更加同邊管理的主題比singleton 基因。

    2006-12-22 15:55:27 補充:

    我們表示, 平均, 複製基因從或完全染色體或單獨基因複製有更長的蛋白質序列、更加功能的領域, 和更加同邊管理的主題比singleton 基因。這種現象不是早先知道的機制,

    2006-12-22 15:55:42 補充:

    譬如蛋白質作用[ 10-13 ], 演變率[ 14, 15 ], 劑量[ 11 ], 和劑量平衡[ 16 ], 那影響基因duplicability 副產物。相反, 看起來起因於次級新functionalization 過程在複製基因演變[ 11 ] 。

    2006-12-22 15:55:52 補充:

    在這個過程之下, 複雜基因是可能被保留在複製以後因為他們是有傾向對subfunctionalization, 並且基因複雜被收復通過隨後neofunctionalization 。因而, 基因複製增加基因數字和基因複雜, 二個重要因素在genomic 和organismal 複雜的起源。

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