Salyers has shown that Bacteroides probably picked up erythromycin-resistant genes from distantly related species of staphylococcus and streptococcus. Although neither bug colonizes the intestine, they are routinely inhaled and swallowed, providing a window of 24 to 48 hours in which they can commingle with intestinal flora before exiting. "That's more than long enough to pick up something interesting in the swinging singles bar of the human colon," she quips.
Most disturbing is Salyers's discovery that antibiotics like tetracycline actually stimulate Bacteroides to begin swapping its resistance genes. "If you think of the conjugative transfer of resistance genes as bacterial sex, you have to think of tetracycline as the aphrodisiac," she says. When Salyers exposes Bacteroides to other bacteria such as Escherichia coli under the disinhibiting influence of antibiotics, she has witnessed the step-by-step process by which the bacteria excise and transfer the tetQ gene from one species to another.
- 柳亭婷Lv 51 0 年前最佳解答
Salyers 表示, Bacteroides 大概被採摘紅黴素抗性基因從遙遠地葡萄球菌和鏈球菌的相關種類。雖然臭蟲不拓殖肚腑, 他們被吸入和定期地被吞下, 提供他們能commingle 與小腸植物群在退出之前24 到48 個小時的窗口。"比足夠長期拾起某事感興趣對搖擺選拔人的冒號的是更酒吧," 她quips
多數干擾是Salyers 的發現, 抗生素像四圜素實際上刺激Bacteroides 開始交換它的抵抗基因。"如果您認為抵抗基因conjugative 調動作為細菌性,
您必須認為四圜素作為春藥," 她說。當Salyers 暴露Bacteroides 於其它細菌譬如大腸埃希氏菌在抗生素的disinhibiting 的影響之下, 她目擊了細菌從一個種類切除和轉移tetQ 基因到另一個的逐步的過程。參考資料： 自己查滴
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