匿名使用者
匿名使用者 發問時間: 社會與文化語言 · 1 0 年前

不好意思幫我翻譯一下這段關於體育的英文文章

不要用翻譯網站的~最好懂的體育或英文這方面的回答喔!感恩~

Low-intensity exercise increas

BACKGROUND: Physical exercise provides health benefits for people with type 2 diabetes mellitus, partly by enhancing skeletal muscle insulin action. We tested the hypothesis that changes in expression of key genes in skeletal muscles relate to exercise-induced improvements in type 2 diabetic patients. METHODS: We determined mRNA expression of 20 selected genes following a self-supervised program of walking (> 150 min per week) over a 4-month period. RESULTS: This level of physical activity improved clinical parameters in approximately half the participants, as determined by reduced hypertension and enhanced insulin sensitivity (defined by reduced plasma-insulin levels and improved homeostasis model assessment (HOMA)). Skeletal muscle mRNA expression of Cbl-associated protein (CAP), diacylglycerol kinase (DGK)delta, uncoupling protein (UCP) 3, nuclear respiratory factor (NRF)-1, and peroxisome proliferator-activated receptor (PPAR)delta tended to increase in type 2 diabetic patients with an improved clinical profile. Skeletal muscle protein expression of PPARdelta and UCP3 was increased significantly after physical exercise in patients with an improved clinical profile, but were unchanged in patients who did not show exercise-mediated improvements in clinical parameters. CONCLUSIONS: This study provides clinical evidence that improvements in insulin sensitivity can be achieved in type 2 diabetic patients after individually executed low-intensity exercise training. Moreover, the positive clinical response to exercise is correlated with changes in skeletal muscle proteins involved in the regulation of mitochondrial biogenesis and metabolism. These changes in skeletal muscle gene expression offer a possible molecular explanation for the improvements in clinical outcomes. Copyright (c) 2006 John Wiley & Sons, Ltd.

2 個解答

評分
  • 1 0 年前
    最佳解答

    輕度運動增加

    背景:

    運動對於有第二型糖尿病的人的健康有好處,因為可以增加肌肉裏的胰島素作用。我們把以上這個假設來做實驗,看看一些關鍵基因表現的改變與第二型糖尿病病人因為做運動而好轉的相互關係。

    方法:

    在四個月的期間,讓病人執行自我管理的步行運動(每個禮拜至少150分鐘),並測量指定的20個基因的mRNA表現。

    結果:

    在這種程度的運動之下,大約有一半的病人臨床指數都有改善,包括高血壓以及胰島素活動的改善(血漿胰島素下降,HOMA改善)。

    CAP, DGK delta, UCP 3, NRF, 以及PPAR的mRNA表現,在經過運動之後臨床情況有改善的第二型糖尿病的病患中都有增加。另外,在經過運動之後有改善的病患中,他們的PPAR delta 和UCP3的肌肉蛋白表現都有相當大的增加,但是運動之後仍沒有改善的病患中,則沒有改變。

    結論:

    這個研究顯示,第二類糖尿病患的胰島素活性,在經過輕度運動訓練之後有改善。而且,我們也可以看出,這些運動所引起的臨床的改善,與粒線體組織與代謝內的的肌肉蛋白的變化有關。這些肌肉基因表現的改變,可以幫助我們由分子的觀點來解釋病患臨床上的改善。

    參考資料: 純手工翻譯
  • 匿名使用者
    7 年前

    參考下面的網址看看

    http://phi008780430.pixnet.net/blog

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