小葵 發問時間: 社會與文化語言 · 1 0 年前

英文翻成中文..

and the mouse strain C. muridarum (MoPn) induced different

patterns of phosphorylation in HeLa cells. More recently,

Clifton et al. reported that a protein tyrosine-phosphorylated

during chlamydial infection (Tarp) was of chlamydial origin

(9). They suggested that Tarp was translocated into the host

cytosol by a chlamydial type III secretion mechanism and that

secreted Tarp facilitated actin rearrangement during entry into

host cells. Altogether, these results, using a limited number of

strains suggested that tyrosine phosphorylation may be critical

to early chlamydia-host interaction and might vary among chla-mydial

strains of differing host and tissue tropism in vivo.

In the present study, we determined the relationship be-tween

chlamydial pathobiotype and the pattern of protein ty-rosine

phosphorylation induced by attachment and entry into

cultured human and murine epithelial cells. We compared

protein tyrosine phosphorylation profiles induced by 15 Chla-mydia

reference serovars, comprising trachoma and lympho-granuloma

venereum (LGV) biovars, the human respiratory

pathogen C. pneumoniae strain AR-39, and two rodent chla-mydial

pathogens, C. muridarum and C. caviae. We report that

protein tyrosine phosphorylation induced by chlamydial infec-tion

in vitro differs with respect to infecting strain and that

these differences directly correlate with chlamydial pathobio-type,

suggesting that they may play an important functional

role in the pathogenesis of infection.

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  • 1 0 年前
    最佳解答

    並且老鼠張力C. muridarum (MoPn) 導致phosphorylation 的不同的樣式在海拉細胞裡。最近, Clifton 等報告,

    蛋白質酚基乙氨酸磷酸化在chlamydial 傳染(篷布期間) 是chlamydial 起源(9) 。他們建議篷布改變了的位置入主人cytosol 由chlamydial 型III 分泌物機制並且被藏匿的篷布促進了肌動蛋白重新整理在詞條期間入寄主細胞。一共, 這些結果, 使用張力的一個有限的數字建議, 酚基乙氨酸phosphorylation 也許及早是重要披衣菌主人互作用, 也許變化在不同的主人和組織tropism 之中chla-mydial 張力in-vivo 。在本研究中, 我們確定了關係在chlamydial pathobiotype 和蛋白質酚基乙氨酸phosphorylation 之間的樣式被附件和詞條導致入被開化的人和鼠科上皮細胞。我們比較了蛋白質酚基乙氨酸phosphorylation 外形被15 披衣菌參考serovars 導致, 包括砂眼並且lympho 肉芽腫venereum

    (LGV) biovars, 人的呼吸病原生物C. pneumoniae 勞損AR-39

    、和二嚙齒目動物chla-mydial 病原生物、C. muridarum 和C. caviae 。我們報告, 蛋白質酚基乙氨酸phosphorylation 被chlamydial 傳染導致在試管內不同談到傳染的張力並且這些區別直接地關聯以chlamydial pathobio 類型, 建議他們也許充當在傳染發病原理的一個重要功能角色。

    參考資料: Yahoo
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