小天 發問時間: 社會與文化語言 · 1 0 年前

生物相關文章....英翻中

Rotenone, a specific inhibitor of mitochondrial complex I, reproduces many features of Parkinson’s disease. The aim of the study was carried out

to investigate how rotenone affected the mitochondrial function and antioxidant/oxidant parameters of mouse striatum, and secondly, to evaluate the

ameliorating effects of catalpol against rotenone-induced damage. Our results showed that rotenone induced significant changes in mitochondrial

function such as complex I activity and mitochondrial membrane potential decreased, and enhanced antioxidant status as glutathione depletion,

enzymatic (glutathione peroxidase and superoxide dismutase) disorders, and increased lipid peroxidation. Catalpol increased complex I, superoxide

dismutase and glutathione peroxidase activities, reduced lipid peroxidation and loss of mitochondrial membrane potential in rotenone-treated mice.

These in vivo data indicated that catalpol might have protection against deleterious mouse damage caused by rotenone.

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    1 0 年前
    最佳解答

    毒魚藤素是一種粒線體第一複合蛋白的特殊抑制物,可以誘發類似巴金森氏症的許多症狀Rotenone, a specific inhibitor of mitochondrial complex I, reproduces many features of Parkinson’s disease.

    此研究的目地為: 探索在老鼠的大腦紋狀體中, 毒魚藤素是如何的影響粒線體的功能 及抗氧化物/氧化物的參數The aim of the study was carried out to investigate how rotenone affected the mitochondrial function and antioxidant/oxidant parameters of mouse striatum,

    再則,評估 Catapol 對毒魚藤素所引發損害的減緩效果and secondly, to evaluate the ameliorating effects of catalpol against rotenone-induced damage.

    我们的研究結果顯示毒魚藤素對粒線體有顯著影響-----如第一複合蛋白活性跟粒線體膜電位的降低,抗氧化需求上升(glutathion穀胱甘缺乏), 酵素失衡( 穀胱甘過氧化脢,超氧化物歧化酵素),增加脂肪的過養化Our results showed that rotenone induced significant changes inmitochondrial

    function such as complex I activity and mitochondrial membrane potential decreased, and enhanced antioxidant status as glutathione depletion,

    enzymatic (glutathione peroxidase and superoxide dismutase) disorders, and increased lipid peroxidation.

    Catapol對毒魚藤素處理過的老鼠的影響是---- 可以增加粒線體第一複合蛋白活性, 增加穀胱甘過氧化脢,超氧化物歧化酵素的活性,減少脂肪的過養化.減少粒線體膜電位的喪失 Catalpol increased complex I, superoxide

    dismutase and glutathione peroxidase activities, reduced lipid peroxidation and loss of mitochondrial membrane potential in rotenone-treated mice.

    這些活體數據申明catapol可能對毒魚藤素在老鼠引發的毒害有著保護的效果These in vivo data indicated that catalpol might have protection against deleterious mouse damage caused by rotenone.

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