Ellects of age on human cumulative irritation responses
JAMES P. BOWMAN, Hill Top Research inc., P.O. Box 138,
Miamluille, OH 45147: ALBERT M. KLIGMAN and
TRACY STOUDEMAYER, S.K.I.N., inc.. 151 East Tenth Avenue,
Conshohocken, PA 19428: and JOSEPH NICHOLSON, Product
Investigations. 75 1 East Tenth Avenue, Conshohockn PA 1 9428.
Accepted frr publication April 4 2005.
A 10-day cumulative irritation test was conducted to evaluate whether or not test subjects 65 years of age and older would rank eleven test materials the same as subjects 15 to 45 years of age The test materials consisted of mild to moderately irritating chemicals. The test articles were ranked similarly tot both groups of subjects. Staiistical analysis indicated no significant difference between the groups of subjects. Thus older subjects should not necessarily be excluded in comparative studies of irritancy.