Tsutena 發問時間: 健康疾病與處置癌症 · 1 0 年前

誰知道這個「腫瘤研究」期刊?

網路看到「懷孕生育可保護母親避免乳癌」的新聞,說這項研究公布在十月號的「腫瘤研究」期刊。想查這篇原文來看,但是怎麼查都沒查到這是什麼期刊。誰知道這個「腫瘤研究」期刊?是哪一國發行的,是美國嗎?期刊的外文原名稱是什麼?這個期刊在網路上有網路報嗎?

(「懷孕生育可保護母親避免乳癌」的新聞 http://tw.news.yahoo.com/article/url/d/a/071003/19... )

1 個解答

評分
  • 1 0 年前
    最佳解答

    期刊 : Cancer Research 2007;67(19):9035-9038.

    篇名 : Fetal Microchimerism in Women with Breast Cancer

    此期刊為美國出版(http://cancerres.aacrjournals.org/)

    除非您有買期刊或網路版, 否則不會有全文資料

    以下附文章摘要供您參考 :

    Fetal microchimerism (FMc) describes long-term persistence of small numbers of fetal-derived allogeneic cells in the mother. Although FMc has been implicated as a mechanism of autoimmune disease, it may confer a beneficial effect with immune surveillance of malignant cells. We hypothesized that allogeneic FMc imparts a protective effect against breast cancer. Two observations provided a rationale for the study hypothesis. First, allogeneic cells convey risk reduction for recurrent malignancy in hematopoietic cell transplantation. Second, reduced risk of breast cancer is well recognized among parous compared with nulliparous women. As an initial test of the hypothesis, we investigated 82 women, 35 with breast cancer and 47 who were healthy, for male DNA in peripheral blood, presumed from a prior pregnancy with a male fetus. The prevalence and levels of male DNA were determined by real-time quantitative PCR for the Y chromosome–specific gene DYS14 in DNA extracted from peripheral blood mononuclear cells. FMc was found significantly more often in healthy women than women with breast cancer (43% versus 14%, respectively). Considering the absence of FMc as a risk factor, the odds ratio was 4.4 [95% confidence intervals (95% CI), 1.34–16.99; P = 0.006]. Restricting analysis to women known to had given birth to a son, the odds ratio was 5.9 (95% CI, 1.26–6.69; P = 0.01). Our findings indicate that allogeneic FMc may contribute to reduction in risk of breast cancer. Further studies are indicated and, if confirmed, extended studies to examine whether allogeneic immune surveillance from FMc is deficient in women with breast cancer.

    希望對您有幫助!!

    參考資料: 醫院工作者
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