匿名使用者
匿名使用者 發問時間: 社會與文化語言 · 1 0 年前

翻譯.....英文期刊導讀(贈15點)

play a part in killing beta cells. But they do know, based on highly sensitive detection tests, that one or more are present at diagnosis in some 70 to 90 percent of patients with type 1 diabetes. Today research laboratories use these tests to diagnose type 1 diabetes and distinguish it from type 2 diabetes, which usually arises in overweight adults and does not stem from autoimmunity.

急需要....幫幫忙,謝謝。

已更新項目:

Surprisingly, such tests have uncovered autoantibodies in about 5 percent of patients otherwise diagnosed with type 2 diabetes, which suggests that those individuals have been misclassified or have a combination of type 1 and type 2 diabetes.)

2 個已更新項目:

Interest in the three autoantibodies escalated with the discovery that they appear long before the onset of diabetic symptoms. In studies conducted by various laboratories, investigators took blood samples from thousands of healthy schoolchildren

3 個已更新項目:

and then monitored the youngsters' health for up to 10 years. When a child came down with type 1 diabetes, the researchers pulled the individual's blood sample out of storage to see whether it contained autoantibodies

4 個已更新項目:

The vast majority of children destined to become diabetic had one or more of the three signature diabetes-related autoantibodies

5 個已更新項目:

in their blood as long as 10 years before any recognizable symptoms arose.

Before this work, some experts thought that type 1 diabetes developed suddenly, perhaps within a matter of weeks

6 個已更新項目:

The new data demonstrated, instead, that in most cases the immune system silently assails the pancreas for years until so many beta cells die that the organ can no longer make enough insulin for the body's needs

7 個已更新項目:

That is the point when the classic early symptoms of diabetes arise, such as excessive hunger, thirst and urination.

8 個已更新項目:

More important, these studies also raised the prospect that doctors might forecast whether a child is at risk for type I diabetes by testing blood for the presence of these autoantibodies. Clinical researchers found

9 個已更新項目:

that an individual with one autoantibody has a 10 percent risk of showing symptoms within five years. With two autoantibodies, the chance of disease jumps to 50 percent; with three autoantibodies, the threat rockets to between 60 and 80 percent.

10 個已更新項目:

The ability to predict whether a person is likely to fall ill with type 1 diabetes has had major repercussions for medical researchers trying to better understand and prevent the disease. Before the discovery of predictive autoantibodies,

11 個已更新項目:

for example, it was almost impossible to conduct clinical trials of new preventive therapies, because the disorder is relatively rare, affecting about one individual in 400. Such odds meant that more than 40,000 subjects would have to be entered into a

12 個已更新項目:

a trial in order to assess the effects of an intervention on the 100 who would eventually be affected.

Now scientists can select for study those people whose blood shows two or more of the diabetes-related autoantibodies, because at least half the subjects, if untreated, will most likely

13 個已更新項目:

With two autoantibodies, the chance of disease jumps to 50 percent; with three autoantibodies, the threat rockets to between 60 and 80 percent.

14 個已更新項目:

The ability to predict whether a person is likely to fall ill with type 1 diabetes has had major repercussions for medical researchers trying to better understand and prevent the disease. Before the discovery of predictive autoantibodies

15 個已更新項目:

for example, it was almost impossible to conduct clinical trials of new preventive therapies, because the disorder is relatively rare, affecting about one individual in 400. Such odds meant that more than 40,000 subjects would have to be entered into

16 個已更新項目:

a trial in order to assess the effects of an intervention on the 100 who would eventually be affecte

17 個已更新項目:

Now scientists can select for study those people whose blood shows two or more of the diabetes-related autoantibodies, because at least half the subjects, if untreated, will most likely come down with the disease within five years. Slashing the number of subjects who must be

18 個已更新項目:

enrolled in a prevention trial has made such experiments feasible for the first time. In one investigation, doctors identified several thousand individuals at high risk of diabetes and tested

19 個已更新項目:

幫幫我!謝謝你。

1 個解答

評分
  • 1 0 年前
    最佳解答

    翻譯為:

    在殺害的貝它細胞扮演一角色。 但是他們確實知道,被基於的高度地敏感的發現測試,一或者更多在患有類型 1 糖尿病的一些 70-90% 病人中的診斷在場。 今天研究實驗室使用這些測試診斷類型 1 糖尿病而且區別它和類型 2 糖尿病,通常在超重的成人中發生而且不起源於 autoimmunity 。

    令人驚訝地,如此的測試已經另外在大約 5% 病人中揭示 autoantibodies 以類型 2 糖尿病,建議那些個體已經被進行錯誤的分類或者有一個類型 1 和類型的組合 2 糖尿病診斷.)

    在與他們在糖尿病癥狀的攻擊之前顯得很長的發現一起擴大的這三 autoantibodies 中感興趣。 在被各種不同實驗室引導的研究中,調查員拿了來自數以千計的健康的學生的血樣本

    在與他們在糖尿病癥狀的攻擊之前顯得很長的發現一起擴大的這三 autoantibodies 中感興趣。 在被各種不同實驗室引導的研究中,調查員拿了來自數以千計的健康的學生的血樣本

    然後監視了兒童的健康達 10 年。 當一個孩子以類型 1 糖尿病落下來的時候,研究人員把個體的血樣本從儲藏拉出來見到它是否包含了 autoantibodies

    相當多的孩子注定變成糖尿病患者有或更多三與簽字糖尿病相關的 autoantibodies

    在他們的血中只要在任何的可認識的癥狀前 10 年引起了。

    在這一個工作之前,一些專家認為類型 1 糖尿病突然發展,在大約數個星期之內也許

    新的資料改為示範在大部份的情形下免疫系統默默地攻擊胰臟長達數年之久直到如此許多貝它細胞骰子以便器官能不再為身體的需要製造足夠的胰島素

    當糖尿病的第一流早癥狀出現,像是過度的饑餓、口渴和撒尿的時候,那是重點。

    更重要的,因為藉由為這些 autoantibodies 的出現嘗試血鍵入我糖尿病,這些研究也升起了醫生可能預測的視野是否一個孩子置於險境。 臨床的研究人員發現

    那一個個體用一 autoantibody 有在五年之內顯示癥狀的百分之 10 風險。 藉由二 autoantibodies,對 50% 的疾病跳躍的機會; 藉由三 autoantibodies ,威脅發射火箭到在 60 而且 80% 之間。

    能力預測是否一個人可能以類型 1 糖尿病生病已經有主要的彈回給嘗試更好了解而且避免疾病的醫療的研究人員。 在預言性 autoantibodies 的發現之前,

    因為混亂相對地很稀有,所以舉例來說,引導新預防的治療的臨床實驗幾乎不可能,在 400 年影響大約一個個體. 如此的機會意謂了超過 40,000個主題將會必須被參與一

    試驗為了要在這 100 誰將會最後被影響上估計干涉的效果。

    現在科學家能為研究血顯示二或更多與糖尿病相關 autoantibodies 的那些人選擇,因為至少一半的主題,如果未經處理的,將最有可能的

    藉由二 autoantibodies,對 50% 的疾病跳躍的機會; 藉由三 autoantibodies ,威脅發射火箭到在 60 而且 80% 之間。

    能力預測是否一個人可能以類型 1 糖尿病生病已經有主要的彈回給嘗試更好了解而且避免疾病的醫療的研究人員。 在預言性 autoantibodies 的發現之前

    因為混亂相對地很稀有,所以舉例來說,引導新預防的治療的臨床實驗幾乎不可能,在 400 年影響大約一個個體. 如此的機會意謂了超過 40,000個主題將會必須被參與

    試驗為了要在這 100 誰將會最後是 affecte 上估計干涉的效果

    現在科學家能為研究血顯示二或者更多與糖尿病相關 autoantibodies 的那些人選擇,因為至少一半的主題,如果未經處理的,將最有可能的在五年之內因疾病而倒下。 減除一定要是的主題的數字

    登記加入預防試驗已經第一次讓如此的實驗能實行。 在一調查中,醫生在糖尿病的高風險識別了數千個個體而且測試了

    翻譯完了 希望對你有幫助

    參考資料: ME
    • 登入以對解答發表意見
還有問題?馬上發問,尋求解答。