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賭神 發問時間: 社會與文化語言 · 1 0 年前

請化學利害的同仁幫忙翻譯STATS的內容

a b s t r a c t

Signal transducers and activators of transcription (STATs) comprise a family of several

transcription factors that are activated by a variety of cytokines, hormones and growth

factors. STATs are activated through tyrosine phosphorylation, mainly by JAK kinases,

which lead to their dimerization, nuclear translocation and regulation of target genes

expression. Stringent mechanisms of signal attenuation are essential for insuring appropriate,

controlled cellular responses. Among them phosphotyrosine phosphatases (SHPs,

CD45, PTP1B/TC-PTP), protein inhibitors of activated STATs (PIAS) and suppressors of

cytokine signaling (SOCS) inhibit specific and distinct aspects of cytokine signal transduction.

SOCS proteins bind through their SH2 domain to phosphotyrosine residues in either

cytokine receptors or JAK and thus can suppress cytokine signaling. Many recent findings

indicate that SOCS proteins act, in addition, as adaptors that regulate the turnover of certain

substrates by interacting with and activating an E3 ubiquitin ligase. Thus, SOCS proteins act

as negative regulators of JAK/STAT pathways and may represent tumour suppressor genes.

The discovery of oncogenic partner in this signaling pathway, more especially in diverse

hematologic malignancies support a prominent role of deregulated pathways in the pathogenesis

of diseases. Fusion proteins implicating the JH1 domain of JAK2 (TEL-JAK2, BCRJAK2),

leading to deregulated activity of JAK2, have been described as the result of translocation.

Somatic point mutation in JH2 domain of JAK2 (JAK2V617F), leading also to constitutive

tyrosine phosphorylation of JAK2 and its downstream effectors was reported in myeloproliferative

disorders. Furthermore, silencing of socs-1 and shp-1 expression by gene methylation

is observed in some cancer cells.

2 個解答

評分
  • 1 0 年前
    最佳解答

    摘要

    信號轉導和轉錄激活(統計) ,包括一個家庭的幾個

    轉錄因子被激活了各種細胞因子,激素和生長

    因素。統計數據是通過激活酪氨酸磷酸化,主要是由jak激酶,

    這導致他們的二聚化,核轉及調控的靶基因

    表達。嚴格機制的信號衰減是必不可少的投保適當的,

    控制細胞的反應。其中磷酸酪氨酸磷酸酶( shps ,

    CD45及ptp1b/tc-ptp ) ,蛋白質抑製劑的激活狀態(影響評估)和鎮壓的

    細胞因子信號( SoC )的抑制具體而鮮明方面的細胞因子信號轉導。

    SoC的蛋白質結合,通過他們的SH2域,以磷酸酪氨酸殘留要么

    細胞因子受體或jak ,從而可以抑制細胞因子信號。許多最近的研究結果

    顯示SoC的蛋白質行為,此外,由於火牛規範的營業額一定

    襯底相互作用,並激活一個泛素連接酶。因此, SoC的蛋白質法

    至於負面的監管jak / Stat的通路與可能代表腫瘤抑制基因。

    發現致癌夥伴,在這一信號轉導通路,特別是在多樣化

    惡性血液病支持的一個突出的作用,放鬆管制的路徑在發病

    疾病。融合蛋白暗示jh1域jak2 (電話- jak2 , bcrjak2 )

    導致放鬆管制活動的jak2 ,被形容為結果的易位。

    體細胞點突變jh2域jak2 ( jak2v617f ) ,領導也構

    酪氨酸磷酸化jak2及其下游效應據報導,在骨髓增生異常

    失常等。此外,沉默的SoC - 1和水電站- 1表達基因甲基化

    是觀察在某些癌細胞。

    參考資料: GOOg le
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  • 匿名使用者
    6 年前

    到下面的網址看看吧

    ▶▶http://qoozoo09260.pixnet.net/blog

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