發問時間: 社會與文化語言 · 1 0 年前

醫學paper 急用拜託 勿用機器翻譯

In recent years, we have come to appreciate that the close association between bone and

vasculature plays a pivotal role in the regulation of bone remodeling and fracture repair. In 2001, Hauge et al.

characterized a specialized vascular structure, the bone remodeling compartment (BRC), and showed that the

outer lining of this compartment was made up of flattened cells, displaying all the characteristics of lining cells

in bone. A decrease in bone turnover leads to a decrease in surfaces covered with remodeling compartments,

whereas increased turnover causes an increase. Immunoreactivity for all major osteotropic growth factors and

cytokines including osteoprotegerin (OPG) and RANKL has been shown in the cells lining the BRC, which

makes the BRC the structure of choice for coupling between resorption and formation. The secretion of these

factors inside a confined space separated from the bone marrow would facilitate local regulation of the

remodeling process without interference from growth factors secreted by blood cells in the marrow space. The

BRC creates an environment where cells inside the structure are exposed to denuded bone, which may enable

direct cellular interactions with integrins and other matrix factors known to regulate osteoclast/osteoblast

activity. However, the denuded bone surface inside the BRC also constitutes an ideal environment for the

seeding of bone metastases, known to have high affinity for bone matrix. Reduction in BRC space brought

about by antiresorptive therapies such as bisphosphonates reduce the number of skeletal events in advanced

cancer, whereas an increase in BRC space induced by remodeling activators like PTH may increase the bone

metastatic burden. The BRC has only been characterized in detail in trabecular bone; there is, however,

evidence that a similar structure may exist in cortical bone, but further characterization is needed.

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  • 小林
    Lv 5
    1 0 年前
    最佳解答

    在近年, 我們來感激近協會在骨頭andvasculature之間在骨頭的規章中起關鍵性作用改塑和骨折修理。 在2001年,豪格et al。 表現一個專業的血管的架構的特性, 骨頭改塑分隔間(BRC), 並且顯示這間分隔間的排隊的theouter由使變平的小屋組成,顯示用線標出cellsin 骨頭的全部特性。 在骨頭營業額方面的減少導致在為改塑分隔間所覆蓋的表面方面的減少,而增加的營業額引起一個增加。 包括osteoprotegerin(OPG)的全部主要的osteotropic增長系數andcytokines的Immunoreactivity 和蘭科爾已經被在小屋用線標出BRC裡顯示, 適合在吸回和形成之間連合whichmakes BRC 選擇的架構。 在裡面thesefactors的分泌 一與骨髓將使theremodeling 過程的地方規章變得容易沒有干擾從以血細胞在骨髓空間內分泌的增長系數那裡分離的有限空間。 TheBRC 建立一種環境, 細胞在架構裡面暴露于剝奪骨頭在那裡,enabledirect有知道管理osteoclast / osteoblastactivity的細胞與相互作用integrins 和其他基體原素哪個。 不過,被剝奪的骨頭表面在BRC裡面也形成骨頭metastases的theseeding的一種理想的環境,知道有骨頭基體的高的密切關係。 象bisphosphonates那樣的antiresorptive治療的在BRC broughtabout 空間方面的削減在advancedcancer裡降低輪廓的事件的數量, 透過象PTH可能增加bonemetastatic 負擔的一樣改塑活化劑引起的鑒于BRC的增加空間。 BRC 只被在trabecular 骨頭裡詳細表現的特性; 不過有一個相似的架構可能在皮的骨頭裡存在,但是更進一步的描述被需要的證據。

    參考資料: Dr.eye
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