Amyloid Precursor Protein 翻譯段落
A fourth candidate gene, apolipoprotein E (apoE), has been identified in a study of sporadically occurring cases by using non-parametric linkage analysis of affected pedigree members of a set of 32 families where 87 out of 293 members suffered from AD.
Amyloid Precursor Protein
•Single transmembrane spanning protein
•Encoded by a single gene on chromosome 21
•Three isoforms generated by alternative splicing of exons 7 & 8
•Small region of the extracellular/transmembrane domain contains the short peptide sequence Aß which is the principal component of (and thought to be a major contributor to the generation of) amyloid placques
Aberrant protein processing ot APP leads to formation of a toxic protein product in enough amounts that cause the the neurodegenerative process to accelerate
- 1 0 年前最佳解答
在32個有受阿耳滋海默氏病症侵襲的血統家庭中,共293人有87人患病.研究中指出血液中 以非參數連鎖分析出偶發性的第四候選基因 apolipoprotein E (apoE).
Amyloid Precursor Protein <---澱粉型態的xx蛋白質 不會翻
以下太多專有名詞 沒唸過的很難懂 我自動放棄 ˇ.ˇ參考資料： 自己