3.1. Effect of tomato extract on APAP-induced hepatotoxicity
Administration of APAP to rats caused a significant elevation of MDA in liver tissue, and decreased the GSH content of the liver to about 50% of control measured 7 days after treatment. Post-treatment with tomato-extract (5 mg/kg) for 7 days (started 1 day after APAP injection) provided significant hepatoprotection and decreased MDA levels and prevented GSH depletion in the liver (p < 0.05) (Table 1). Histopathological studies also revealed that APAP imposed focal necrosis, pyknosis, disorganized sinusoid, hemorrhage, degeneration and infiltration of lymphocytes around the central veins (Table 2). Necrosis, hemorrhage and infiltration were markedly prevented by post-treatment with tomato extract administration (Table 2).
3.2. Effect of tomato extract on ADN-induced pulmonary toxicity
ADN-induced lipid peroxidation in the lung tissue and the levelof TBARS was significantly higher in the lungs of rats received ADNthan in control rats. The level of GSH was also about 50% lower inthe lungs of rats received ADN than in control rats. Co-administrationof the tomato extract for 10 days with ADN significantly restoredGSH content of the lung tissue and prevented lipidperoxidation induced by ADN (Table 3). Histopathological studiesrevealed that ADN imposed acute and chronic inflammation, hem-
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行政氨酚大鼠造成了顯著升高MDA的肝組織，並降低了GSH含量的肝臟約50 ％的控制測量後7天內的待遇。後處理番茄提取物（ 5毫克/千克） 7天（ 1天開始後，氨酚注射）提供了重要的hepatoprotection和降低MDA含量，並阻止穀胱甘肽耗盡肝臟（ p “ 0.05 ） （表1 ） 。病理組織學研究還表明，氨酚實行灶性壞死，固縮，雜亂無章血竇，出血，變性和浸潤淋巴細胞圍繞中心靜脈（見表2 ） 。壞死，出血和滲透明顯預防治療後的番茄提取管理（見表2 ） 。
ADN引起的脂質過氧化的肺組織和levelof TBARS顯著高於在肺部的影響收到ADNthan對照組。水平的穀胱甘肽也約50 ％降低inthe大鼠肺部收到比對照組。聯合administrationof番茄中提取了10天，並顯著restoredGSH內容的肺組織，並阻止lipidperoxidation誘導和（見表3 ） 。病理學studiesrevealed ，並實行急性和慢性炎症，出血，參考資料： me