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Effect of FGF-2 and melatonin on implant bone healing:

a histomorphometric study

Masaaki Takechi Æ Seiko Tatehara Æ

Kazuhito Satomura Æ Kenji Fujisawa Æ

Masaru Nagayama

Abstract Melatonin influences the release of growth

hormone and cortisol in humans, and it was recently

reported that it promoted bone formation. On the other

hand, fibroblast growth factor-2 (FGF-2) was reported to

facilitate the proliferation of osteoblasts. In the present

study, we examined the effect of recombinant human FGF-

2 and melatonin on the promotion of osteogenesis around

titanium implants. Twenty-four 10-week-old female rats of

the Wistar strain received titanium implants in both tibiae.

In the experimental groups, 100 mg/kg body weight of

melatonin was administered by intraperitoneal injection for

4 weeks after implantation and 10 lg of FGF-2 was locally

injected around the implant sites 5 days after implantation.

The control groups were administered saline only. In the

control group, few newly formed bone could be seen

around the implants. It was observed to be in direct contact

with the implant surface, but otherwise unmineralized

connective tissue was occasionally interposed. In the

experimental group, newly formed bone was observed

around the titanium implant. In addition, in contrast to the

control group, abundant bone trabeculae were seen in the

medullary canal region. Bone trabeculae were directly

connected to existing cortical bone. These results strongly

suggested that melatonin and FGF-2 have the potential to

promote osseointegration.

2 個解答

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  • 匿名使用者
    1 0 年前
    最佳解答

    成纖維細胞生長因子的影響- 2和褪黑激素對種植體骨癒合:

    一學研究

    昌明武智Æ精工Tatehara Æ

    仁Satomura Æ賢治藤澤Æ

    永山總裁

    摘要褪黑激素的釋放影響經濟增長

    激素和皮質醇的人類,這是最近

    報告說,它促進骨形成。其他

    另一方面,成纖維細胞生長因子- 2 (成纖維細胞生長因子- 2 )據報導

    促進成骨細胞的增殖。在本

    研究中,我們研究了重組人成纖維細胞生長因子

    2 ,褪黑激素對促進成骨周圍

    種植體。 24個10週歲的雌性大鼠

    應變的只收到種植體在脛骨。

    在實驗組, 100毫克/公斤體重的

    褪黑激素是由腹腔注射的

    4週後植入和10個LG電子的成纖維細胞生長因子- 2是當地

    周圍注射植入網站5天內植入後。

    對照組的管理生理鹽水只。在

    對照組,幾個新成立的骨骼可以被看作

    種植體周圍。有人將直接接觸

    與種植體表面,但在其他unmineralized

    結締組織偶爾插話。在

    實驗組,新成立的骨觀察

    圍繞鈦種植體。此外,在對比的是

    對照組,豐富的骨小梁出現在

    延髓運河區。骨小梁直接

    連接到現有的皮質骨。這些結果強烈

    建議,褪黑激素和FGF - 2有可能

    促進骨。

  • 1 0 年前

    翻譯了應該是這樣八

    在對植入器之上的效果骨頭治癒:

    一項 histomorphometric 研究

    Masaaki Takechi A Seiko Tatehara A

    Kazuhito Satomura A Kenji Fujisawa A

    Masaru Nagayama

    抽象的 Melatonin 影響生長的釋放

    在人類中的荷爾蒙和 cortisol,而且它最近

    報告,它促進了骨頭形成。 在另一個上

    手,纖維母細胞生長因素-2(FGF-2) 被指出了

    促進造骨細胞的增殖。 目前

    研究,我們調查了 recombinant 的效果

    參考資料: 英文課本
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