麻煩懂病理學的幫我翻譯一下(翻成中文)

應該是一份關於前列腺癌的切片檢查

急需阿一"一

The expected reaction in the differential diagnosis of a single individual cell pattern is shown in Table 5.Our recommended panel in the posttreatment setting is CK AE1/AE3,with the triple cocktail of AMACR, p63, and HMCK 34βE12 or CK5/6. Cytokeratin AE1/AE3 highlights subtle carcinoma cells with marked treatment effect and can provide a better estimate of cancer burden in the needle biopsy. α-Methylacyl coA racemase expression is directly proportional to the severity of the therapy effect and may not be helpful in cases with a marked effect.17 The use of proliferation markers to assess tumor viability is considered experimental at this point, but may be ordered, based on the institutional preference of the pathologists and treating physicians.

SUMMARY

The availability of basal cell–associated markers, prostate cancer–associated marker AMACR, and prostate lineage–specific markers PSA and PSAP provide significant, objective evidence in confirming whether glandular lesions are benign or malignant and whether they are of prostatic origin. Although these markers provide invaluable ancillary diagnostic assistance, the myriad differential diagnostic considerations and overlapping staining reactions mean that the final diagnosis must reflect the context and be correlated with the original H&E-derived diagnosis. We recommend an immunohistochemical panel approach based on the differential diagnostic scenario as the best practice for distinguishing prostate cancer and its mimics in needle core biopsies.

2 個解答

評分
  • 奎雅
    Lv 4
    1 0 年前
    最佳解答

    在一個唯一單獨細胞樣式的有差別的診斷的期望的反應在表5.Our里顯示推薦了在後處理設置的盤區是有AMACR三倍雞尾酒的CK AE1/AE3, p63,并且與明显治療的HMCK 34βE12或CK5/6. Cytokeratin AE1/AE3聚焦微妙的癌細胞影響并且可能提供癌症負擔的一個更好的估計在針切片檢查法的。 α-Methylacyl coA racemase表示是正比例的對療法作用的嚴肅,并且可能不是有用的在與明顯的effect.17的案件使用擴散標誌估計腫瘤生活能力這時被认为實驗性,但是也许根據病理學家和對待的醫師的協會特選被预定。

    總結 基礎細胞有關的標誌的可及性,前列腺癌症伴生的標誌AMACR和前列腺後裔具體標誌PSA和PSAP提供在證實腺損害是否良性或惡性,并且他們是否的重大,客观凭证是前列腺的起源。 雖然這些標誌提供無價的輔助診斷援助,無數的有差別的診斷考慮和重疊弄髒反應意味着必须反射上下文和關聯最後的診斷與原始的H& E獲得的診斷。 我們推薦根据有差別的診斷情景的一種immunohistochemical盤區方法作为區別前列腺癌的最优方法,并且它的針的仿造物挖出果核切片檢查法。

    參考資料: Oneself
  • 6 年前

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