河馬貓 發問時間: 健康其他:保健 · 1 0 年前

藥物副作用

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955 Ultracet tab(Tramadol 37.5mg+Acetaminophen 325mg)(管四)

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2 個解答

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  • jaidar
    Lv 5
    1 0 年前
    最佳解答

    關於

    Ultracet tab(Tramadol 37.5mg+Acetaminophen 325mg)(管四)

    所有side effection.

    1.Tramadol: 發汗,眩暈, 嘔吐, 口乾疲勞.

    2.Acetaminophen:

    A.過敏症...如有發生應停止可藥.

    B.胃腸道:偶有嘔心,嘔吐.食慾不振.

    C.血液:偶有皿小坂減少症,顆粒減少症需仔

    細觀察,間有有發紺症狀,停止使用.

    參考資料: TDR2005
  • waewae
    Lv 6
    1 0 年前

    以下資訊給您參考

    Ultracet 第四級管制藥

    Supply: Each tab contains:

    Tramadol Hydrochloride´´´´´´…´´37.5mg

    Acetaminophen´´´´´´´´´´´´´´´´´´´´´´ 325mg

    Description: This drug is a member of the opioid/acetaminophen combination class.

    Action: Tramadol is a centrally-acting opioid analgesic. The drug and its O-demethylated metabolite bind to mu opioid receptors, with the metabolite having substantially higher binding affinity (about 200-fold); the metabolite is up to 6 times more potent in producing analgesia than parent compound in animal models. Acetaminophen is a nonopioid analgesic which inhibits prostaglandin synthetase activity in the central nervous system.

    Pharmacokinetics: Onset:<60 min; Duration: 4-6 hrs; Half-life: acetaminophen 2- 3 hrs ; tramadol 5 -6 hrs. Excretion from renal acetaminophen less than 10% unchanged; tramadol 30% unchanged.

    Indication: 使用非鴉片類止痛劑無效的中度至嚴重性疼痛。

    健保給付規定:限用於中度至嚴重性疼痛之病人,須符合下述條件:

    1. 經其他止痛藥、或非類固醇抗發炎藥物(NSAIDs)治療後仍無法控制疼痛或有嚴重副作用者。

    2. 非癌症病患使用超過五天時,須檢附疼痛評估報告,並每隔三個月再評估乙次,內容須包括疼痛強度及疼痛緩解的VAS與VRS(Visual Analogue Scale 和Verbal Rating Scale)。

    Dosage and Administration:

    Adult.1 -2 tab q4-6h, Max : 8 tab/day

    Pediatric,Children up to 16 years ediatric data for the fixed combination are unavailable.

    Adverse drug reaction: Rare: allergic reaction; anaphylactoid reactions; chest pain; seizures

    Contraindication: Contraindicated use in patient with hypersensitivity to acetaminophen or opioids or tramadol.

    Caution:

    1. Abrupt discontinuation may induce withdrawal symptoms (ie, anxiety, sweating, nausea, diarrhea, tremors, insomnia).

    2. Risk of acetaminophen hepatotoxicity is increased in alcoholics/ chronic alcohol abusers.

    3. Use in caution in pt’s with head trauma, increased intracranial pressure, respiratory depression, and abdominal conditions.

    Pregnancy category: Tramadol – C; Acetaminophen - B

    Reference:

    1. USP DI 26th 2006.

    2. 1974-2007 Thomson MICROMEDEX.

    3. Drug Package Insert.

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