匿名使用者
匿名使用者 發問時間: 社會與文化語言 · 1 0 年前

醫學摘要.翻譯問題? (英>中)

請問下面翻譯怎麼翻譯阿?

因為看不懂 要報告 很急

所以來請教別人ˊˋ

不要用網路翻譯直接貼澳 因為要通順,謝謝麻煩了!

We have recently shown that a cocktail containing two leishmanial recombinant antigens (LmSTI1 and TSA)

and interleukin-12 (IL-12) as an adjuvant induces solid protection in both a murine and a nonhuman primate

model of cutaneous leishmaniasis. However, because IL-12 is difficult to prepare, is expensive, and does not

have the stability required for a vaccine product, we have investigated the possibility of using DNA as an

alternative means of inducing protective immunity. Here, we present evidence that the antigens TSA and

LmSTI1 delivered in a plasmid DNA format either as single genes or in a tandem digene construct induce

equally solid protection against Leishmania major infection in susceptible BALB/c mice. Immunization of mice

with either TSA DNA or LmSTI1 DNA induced specific CD4-T-cell responses of the Th1 phenotype without

a requirement for specific adjuvant. CD8 responses, as measured by cytotoxic-T-lymphocyte activity, were

generated after immunization with TSA DNA but not LmSTI1 DNA. Interestingly, vaccination of mice with

TSA DNA consistently induced protection to a much greater extent than LmSTI1 DNA, thus supporting the

notion that CD8 responses might be an important accessory arm of the immune response for acquired

resistance against leishmaniasis.

1 個解答

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  • 最佳解答

    我們最近已經顯示一種雞尾酒(包含兩種leishmanial recombinant抗原(LmSTI1和TSA))

    以及interleukin-12(IL-12) 當時一輔助固體保護在murine 和非人類大主教

    皮膚leishmaniasis的模型。 不過,因為IL-12 難被準備,是昂貴的,並且不

    讓人把穩定要求一種疫苗產品,我們已經調查使用DNA 作為A的可能性

    引起保護免疫的其它的方法。 這裡,我們給證據那抗原TSA 和

    LmSTI1在一plasmid DNA 形式內交付或者作為單個的基因或者在串行digene 架構內引起

    同樣固體的對Leishmania的保護措施易受影響的BALB/c老鼠的較大的感染。 老鼠的免疫注射

    由於TSA DNA 或者LmSTI1 DNA 引起Th1 phenotype的具體的CD4 T 細胞回應沒有

    具體輔助的要求。 CD8 回應,象以cytotoxic T 淋巴細胞活動測量的那樣,

    用TSA在免疫注射之後產生DNA 但不是LmSTI1 DNA。 有趣的是,接種疫苗老鼠有

    對巨大得多的範圍一貫引起保護的TSA DNA LmSTI1 DNA,因此支援

    理念那CD8 回應可能在重要附件臂的那些免疫回應用於獲得

    對leishmaniasis的抵抗。

    大概就這樣^_^

    參考資料:
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