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CALCIUM SUPPLEMENTATION AND BONE

MINERAL ACCRETION IN ADOLESCENT GIRLS;

AN 18-MO RANDOMIZED CONTROLLED

TRIAL WITH 2-Y FOLLOW-UP

Osteoporosis may be prevented by increasing peak

bone mass or decreasing the rate of bone loss with aging.

Calcium supplementation of the diet could result in a greater

Peak bone mass and hence could reduce the risk of fracture

in later life. It could also reduce fractures are related to low bone

mineral density (BMD).

A recent meta-analysis of 19 studies performed in

2859 children reported that calcium supplementation

Increased the bone density of the total body (and arms) in

effects were small(~2%) and were not present at the spine or

hip, the sites relevant to the most important fractures in later

life. The benefits of the supplements on the total-body BMD

were reversible after supplementation was stopped. The

analysis did not find any effect of sex, pubertal stage,

ethnicity, calcium intake, or physical activity. The

researchers designed the present study to address the many

limitations of previous studies on this topic. The study was

designed to include girls with low baseline calcium intakes,

to use state-of-the-art devices(fan-beam dual-energy X-ray

absorptiometry and 4 bone turnover markers), to use a soluble

form of calcium as calcium citrate malate (CCM) dissolved in

a fruit drink, and to include an offset period.

The trial was an 18-mo randomized trial of calcium

Supplement withdrawal. Subjects were 96 girls (mean age;

12y) with low calcium intakes (mean: 636mg/d). The main

Outcome measure was change in total-body, lumber spine,

And total hip bone mineral content (BMC) during.

Changes in BMD and bone turnover markers were

secondary outcome measures.

已更新項目:

The mean additional calcium intake in the supplemented

Group was 555mg/d. Compared with the control group, the

Supplemented group showed significantly greater gains in

BMC (except at the total hip site )over the 18-mo study.

BMD change was significantly greater for all skeletal sites,

2 個已更新項目:

And concentrations of bone resorption markers and

parathyroid hormone were significantly lower in the

supplemented group than in the control group after 18 mo.

After 42 mo, gains in BMC and BMD and differences in

bone resorption were no longer evident.

3 個已更新項目:

In this study, the effect of a nondairy dietary calcium

supplement on bone mineralization was explored in a cohort

of healthy adolescent girls with low baseline calcium

Intakes, and the mechanism for an effect was investigated.

The results show that an increase in calcium intake

4 個已更新項目:

averaging 555mg/d, as CCM in a fruit drink, increased bone

mineral gain in 11 to 12-y-old girls with a low mean baseline

calcium intake of 636 mg/d. Supplementation had most marked

effects on rates of bone mass accretion during the first 6 to

12mo.

1 個解答

評分
  • 最佳解答

    補充鈣和骨

    礦產沖積少女;

    一個 18莫隨機對照

    審判,2 -輜後續行動

    可預防骨質疏鬆,增加高峰

    骨量減少或骨質流失率隨著年齡。

    補鈣的飲食可能導致更大的

    峰值骨量,從而可減少骨折的危險

    在以後的生活。它還可以減少骨折是與低骨

    骨密度(BMD)。

    最近的一項薈萃分析研究,演出19

    報告說,2859兒童補鈣

    增加骨密度的全身(和武器)的

    影響小(〜2%),當時不在場或脊椎

    髖關節的網站相關的最重要骨折後

    生命。所帶來的好處的補充對全身骨密度

    是可逆的補充後,已停止。那個

    分析沒有發現任何影響性別,青春期階段,

    種族,鈣的攝入量,或體力活動。那個

    研究人員設計了本研究,以解決眾多

    以前的研究的局限性就這一議題。這項研究是

    設計,包括女孩與鈣的攝入量低的基準,

    利用國家的先進設備(扇形束雙能X線

    骨密度和骨代謝指標 4),使用可溶性

    形式作為鈣檸檬酸鈣蘋果(CCM)的溶解

    水果飲料,並包括一個偏移時期。

    這項試驗是一個 18模隨機試驗鈣

    補編撤出。受試者為 96女生(平均年齡;

    12y)鈣的攝入量低(平均:636mg / d)項。主要

    結果措施是改變全身,腰椎,

    全髖關節和骨礦含量(BMC)中。

    骨密度變化與骨代謝標誌物

    二次結果的措施。

    平均增加鈣的攝入量的補充

    集團 555mg /天與對照組,

    補充組發現在顯著更大的收益

    BMC(除在全髖網站)的18模研究。

    骨密度變化顯著更大的所有骨骼部位,

    和濃度和骨吸收指標

    甲狀旁腺激素顯著降低了

    補充組比對照組模後 18。

    經過 42開,收益在BMC和BMD和分歧

    骨吸收已不再明顯。

    在這項研究中,影響了非乳製膳食鈣

    補充骨礦化的隊列研究

    少女的健康低基線鈣

    攝入量,以及機制的效果進行了研究。

    結果表明,增加鈣的攝入量平均在555mg /天,為澳門文化中心的水果飲料,

    礦產收益11至12 - Y型歲的女孩低平均基線

    鈣攝取 636毫克/天補充了最顯著

    影響骨量率在第一次積 6 12mo。

    增加的BMC和BMD陪同

    相對減少骨代謝指標,是否定的

    不再存在2撤出後,之後的補充。

    這項研究的結論相矛盾的

    薈萃分析的鈣質補充是無效的

    促進骨礦化脊柱和臀部,在

    增長。

    它同意的結論,即鈣

    補充是有效的全身,而

    效果.本研究可能不同於

    結果的薈萃分析在他們所研究的女孩

    選擇低鈣攝入量的基準

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