Tsai 發問時間: 科學生物學 · 1 0 年前

Expression Quantitative Trait

請問Expression Quantitative Trait Loci是什麼呢?

和Quantitative Trait Loci有何不同?

有誰可以簡單解釋一下嗎?

謝謝

已更新項目:

非常謝謝你,這答案正是我需要的

如果方便的話可以再幫我看看這張圖表嗎?

http://www.nature.com/nature/journal/v461/n7265/fi...

我該如何解釋呢?

我不懂

minor allele frequency, effect sizes, common and rara variation of SNPs

對於GWAS結果判定的影響(是不是也和control族群的選擇有關呢?)

因為要交報告,可是我對GWAS真的很不了

謝謝你

1 個解答

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  • C C
    Lv 6
    1 0 年前
    最佳解答

    Expression Quantitative Trait Loci, or eQTL, is basically a QTL where the phenotype is the expression of a particular gene.

    In genetic mapping, QTL mapping is looking for a locus (genotype) that influences a quantitative trait (phenotype) such as height, BMI, diabetes, cancer, etc. But in eQTL mapping, the phenotype is the expression level of a gene or a set of genes, rather than a 'conventional' phenotype. In essence, an eQTL is a locus where the variation in the locus is known to influence the expression level of a downstream gene, while a QTL is a locus where the variation in the locus is known to influence a physical phenotype or disease phenotype (possibly through modulating the expression of a downstream gene).

    Does that make sense? I can explain more if needed.

    2010-06-07 22:03:40 補充:

    gwas is right down my alley of expertise. why don't you email me or post a new question, it's pretty painful to answer using the comments here.

    參考資料: I'm a graduate student in human genetics
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