星雨 發問時間: 社會與文化語言 · 9 年前

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4.3.2. The health risk of GAs in potatoes is not so large, and

assumptions made relate to a worst case situation

In published epidemiological studies, the toxic doses may have

been underestimated. It is known that some data from published

studies are old and the measurements may have been uncertain.

Therefore, there is a reason to believe they are biased. The exposures

reported were often means for a group of poisoned persons,

roughly estimated from the potatoes consumed (estimated portions),

measured GA content (any precise sampling impossible)

and bodyweight, after clinical manifestation of toxic effects. It is

very likely that each individual had its own unique exposure level.

Those experiencing truly adverse effects may have been exposed to

higher levels than the reported mean.

The persons suffering from GA exposure were also very likely

more sensitive to GAs. These cases of extreme sensitive persons

were then used for all individuals in the population as a starting

point for the risk assessment. So there is no need for intra-species

extrapolation. The worst case assumption is that anyone exposed

above the critical exposure dose (1 mg/kg b.w./day) is at risk (zero

intra-species differences). This fixed limit value used is probably

appropriate for sensitive individuals, and therefore most individuals

in a population will have a higher individual critical exposure

dose. Using a fixed limit value will therefore almost surely overestimate

the number of cases of poisoning in a population. A model

for integrated probabilistic risk assessment where individual exposure

and individual sensitivity to effects are simultaneously modeled

has been described recently (Van der Voet and Slob, 2007)

and seems to be also a good step forward to improve of a quantitative

risk assessment for potato GAs.The GAs content was measured in fresh, peeled potatoes. The

potatoes actually consumed may contain more GAs due to storage.

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  • 9 年前
    最佳解答

    4.3.2. 氣體的健康風險在土豆的不是那麼大,和做的假定與一個最壞情况情況關連在出版役學研究中,毒性藥量也許有被低估。 知道從出版的一些數據研究是老,並且測量也許是不定的。所以,有原因相信他們是偏心的。 曝光報告了經常一個小組的手段被毒害的人,大致估計從被消耗的土豆(估計的部分),被測量的GA內容(不可能任何精確的採樣) 並且體重,在毒性作用的臨床顯示以後。 它是很可能單獨的其中每一有它自己獨特的曝光水平。體驗真實地不利影响的那些也許被暴露了更高的水平比報告的手段。遭受GA曝光的人也是很可能敏感對氣體。 極端敏感人這些事例 為所有個體然後使用了在人口作為開始风险评估的點。 因此沒有對種內的需要推測。 最壞情况假定是任何人暴露了在重要暴露劑量(1 mg/kg b.w./day)之上是危險的(零種內的區別)。 半新的這個固定的极限值大概是為敏感個體並且多数個體合適在人口將有更高的單獨重要曝光藥量。 因此使用一個固定的極限值幾乎肯定將過高估計案件的數量毒害在人口。 一個模型為單獨曝光的聯合機率風險評估並且對作用的單獨敏感性同時被塑造最近被描述了(範・ der Voet和粗俗漢2007) 並且似乎也是改善的一個好進步定量土豆GAs.The氣體容量的風險評估在新鲜,被剝皮的土豆被測量了。 實際上被消耗的土豆也許包含更多氣體由于存貯

    參考資料: 奇摩翻譯
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