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Background: The incidence of cardiovascular diseases increases

after menopause, and soy consumption is suggested to inhibit disease

development.

Objective: The objective was to identify biomarkers of response to

a dietary supplementation with an isoflavone extract in postmenopausal

women by proteome analysis of peripheral blood mononuclear

cells.

Design: The study with healthy postmenopausal woman was performed

in a placebo-controlled sequential design. Peripheral mononuclear

blood cells were collected from 10 volunteers after 8 wk of

receiving daily 2 placebo cereal bars and after a subsequent 8 wk of

intervention with 2 cereal bars each providing 25 mg of isoflavones.

The proteome of the cells was visualized after 2-dimensional gel

electrophoresis, and peptide mass fingerprinting served to identify

proteins that by the intervention displayed altered protein concentrations.

Results: Twenty-nine proteins were identified that showed significantly

altered expression in the mononuclear blood cells under the

soy-isoflavone intervention, including a variety of proteins involved

in an antiinflammatory response. Heat shock protein 70 or a

lymphocyte-specific protein phosphatase and proteins that promote

increased fibrinolysis, such as -enolase, were found at increased

intensities, whereas those that mediate adhesion, migration, and

proliferation of vascular smooth muscle cells, such as galectin-1,

were found at reduced intensities after soy extract consumption.

Conclusion: Proteome analysis identified in vivo markers that respond

to a dietary intervention with isoflavone-enriched soy extract

in postmenopausal women. The nature of the proteins identified

suggests that soy isoflavones may increase the antiinflammatory

response in blood mononuclear cells that might contribute to the

atherosclerosis-preventive activities of a soy-rich diet. Soy, isoflavones, cardiovascular disease, postmenopausal

women, peripheral blood mononuclear cells, proteome,

heat shock protein 70

2 個解答

評分
  • 10 年前
    最佳解答

    背景: 心血管疾病增量的發生在更年期和大豆消耗量以後被建議禁止疾病發展。宗旨: 宗旨將辨認反應biomarkers 與異黃酮萃取物的一個飲食補充在由單核對周邊血液的proteome的分析的绝經後的婦女細胞。設計: 與健康绝經後的婦女的研究被进行了在一個安慰劑受控連續設計。 周邊單核血细胞從10個志願者收集了在8星期以后 接受日報2安慰劑穀物酒吧和在隨後8星期干預以后用2穀物禁止異黃酮每提供的25毫克。細胞的proteome在二維膠凝體以後形象化電泳法和肽許多指紋識別服务辨認由被顯示的干預修改蛋白質含量的蛋白質。結果: 在單核血细胞顯示显著修改過的表示在之下的二十九蛋白質被辨認了大豆異黃酮干預,包括在一個抗發炎反應介入的各種各樣的蛋白質。 熱震動蛋白質70或a 促進的淋巴細胞具體蛋白質磷酸酶和蛋白質增加的纖維蛋白溶解作用,例如- enolase,被找到在增加強度,而斡旋黏附力,遷移,和的那些血管平滑肌细胞的擴散,例如galectin-1,被找到在減少的強度,在大豆萃取物消耗量之後。結論: Proteome分析辨認了反應與異黃酮被豐富的大豆萃取物的飲食干預的活體內標誌在绝經後的婦女。 辨認的蛋白質的本质建議大豆異黃酮也許增加抗發炎在也許造成的血液單核細胞的反應富有大豆的飲食的動脈粥樣硬化預防活動。 大豆,異黃酮,心血管疾病,绝經後婦女,周邊血液單核細胞, proteome,熱震動蛋白質70

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  • 10 年前

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