發問時間: 社會與文化語言 · 10 年前

醫學英文摘要翻譯

a b s t r a c t

Osteoclasts play a crucial role in bone resorption. Since osteoclast differentiation/activation

is involved in orthodontic tooth movement at the compression sites, the investigation on

osteoclasts is very important to the field of orthodontics. It is well known that estrogen has

the protective effect on bone. However, the mechanisms by which estrogen prevents bone

loss remain to be elucidated. Although estrogen was recently reported to induce apoptosis of

osteoclasts, the precise mechanisms of estrogen-induced osteoclast apoptosis remained

controversial with regard to whether estrogen affects osteoclasts directly or not. Here we

investigated whether estrogen directly induces differentiation and apoptosis of osteoclasts

in vitro using mouse monocytic RAW264 cells differentiated into osteoclasts by RANKL. It

was observed that estrogen inhibited RANKL-induced osteoclast differentiation of RAW264

cells in a dose-dependent manner. Estrogen suppressed p38 phosphorylation while it

enhanced ERK phosphorylation induced by RANKL, suggesting that modulation of MAPK

signaling may be involved in inhibition of osteoclast differentiation by estrogen. Next, it was

shown that estrogen dose-dependently augmented caspase-3 activation in osteoclasts

differentiated from RAW264 cells by RANKL, demonstrating that estrogen directly enhanced

apoptosis of osteoclasts. Estrogen-induced caspase-3 activation was attenuated by ICI

182,780, suggesting that the effects of estrogen on osteoclast apoptosis is mediated through

estrogen receptors. Thus, these results suggest that estrogen may directly inhibit differentiation

and induce apoptosis of osteoclasts.

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[盡量不要線上翻譯 感恩

3 個解答

評分
  • 匿名使用者
    6 年前

    到下面的網址看看吧

    ▶▶http://qoozoo09260.pixnet.net/blog

  • 10 年前

    摘要

    蝕骨細胞在骨質再吸收扮演關鍵的角色。…

    (問題太長會被檢舉移除)

  • 匿名使用者
    10 年前

    一個 B的Tř一個 C噸

    破骨細胞發揮著至關重要的作用骨吸收。由於破骨細胞分化/激活

    參與了正畸牙齒移動在壓縮地盤,調查研究

    破骨細胞是非常重要的領域正畸。這是眾所周知,雌激素

    對骨的保護作用。然而,雌激素機制,預防骨骼

    虧損仍有待澄清。雖然最近向雌激素誘導凋亡

    破骨細胞的確切機制雌激素誘導的破骨細胞凋亡仍

    爭議,至於是否會影響破骨細胞的雌激素直接或沒有。在這裡,我們

    調查是否雌激素直接誘導破骨細胞分化和凋亡

    利用小鼠單核細胞在體外分化成破骨細胞 RAW264由RANKL的。這

    與會者指出,雌激素能抑制RANKL的誘導破骨細胞分化RAW264

    細胞具有劑量依賴性。雌激素抑制p38的磷酸化,而它

    增強 ERK的磷酸化誘導 RANKL的,這表明MAPK的調節

    信號可能參與了抑制破骨細胞分化的雌激素。接著,又有

    結果表明,雌激素劑量依賴性增強 caspase - 3的激活破骨細胞

    從 RAW264分化細胞 RANKL的,這表明雌激素直接提高

    破骨細胞凋亡。雌激素誘導的caspase- 3活化減弱卜內門

    182,780,表明雌激素對破骨細胞介導的細胞凋亡是通過

    雌激素受體。因此,這些結果表明,雌激素可直接抑制分化

    破骨細胞,並誘導凋亡。

    相信我吧!

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