急! 請幫忙翻譯這篇paper (20點)

題目:Assessment of plasma concentrations of ()-epigallocatechin gallate in mice

following administration of a dose reflecting consumption of a standard green

tea beverage

a b s t r a c t

The plasma exposure of ()-epigallocatechin gallate (EGCg) is typically assessed following administration

of EGCg at doses equivalent to the consumption of at least 10 cups of green tea in one sitting. This study

determines the plasma concentrations of EGCg in mice following administration of a dose reflecting typical

consumption of one standard green tea beverage. Swiss Outbred mice were orally administered

0.76 mg/kg EGCg, and using a validated HPLC method, the Cmax of un-conjugated and total EGCg was

determined to be 31.5 ± 3.3 and 34.3 ± 2.0 nM, respectively (mean ± s.d., n = 3–5). The area under the

plasma concentration versus time curve for un-conjugated and total EGCg was 114.3 ± 4.1 and

116.4 ± 4.1 nMh, respectively (mean ± s.d., n = 3–5). To minimise potential ex vivo plasma degradation,

a novel stabilizing solution of 20 mM ascorbic acid (AA) and 13 mM tris[2-carboxyethyl]phosphine

hydrochloride (TCEP) was employed. Comparative evaluation of the efficacy of the 20 mM AA and

13 mM TCEP stabilizing solution to the commonly used stabilizing solution of 114 mM AA and

0.13 mM Na2EDTA, indicated that the AA/TCEP solution provided significantly greater (p < 0.05) protection

to EGCg than the AA/Na2EDTA stabilizing solution. Overall, this study demonstrates that plasma concentrations

of EGCg are in the low nM range following oral administration to mice at a dose reflecting the

consumption of a standard green tea beverage. In addition, a novel stabilizing solution has been identified

which may be useful in stabilizing plasma samples obtained from pharmacokinetic studies.

英文程度不佳 上google翻譯很奇怪

有人能跟我說說這篇題目及摘要部份大概在說些什麼嗎? 謝謝你的幫忙

1 個解答

評分
  • 7 年前
    最佳解答

    題目:在小鼠體內的血漿中濃度變化的評估()- 表沒食子酸酯

    以下給藥劑量反映了一個標準的綠色消費

    茶飲料

    A B S T R A C T

    等離子體暴露()- 表沒食子酸酯(EGCG)是典型的評估下列管理

    研究EGCG劑量相當於至少10杯的綠茶的消耗於同一次考試。本研究

    確定反射典型劑量給藥後的小鼠的血漿中濃度的EGCG

    消耗一個標準綠茶飲料。瑞士遠交小鼠口服

    0.76 mg / kg的EGCG,並使用驗證的高效液相色譜法,未結合時Cmax和總EGCG

    確定為31.5±3.3和34.3±2.0納米,分別為(平均值±標準差,n=3-5)。下的面積

    血漿濃度與時間的曲線為未共軛的和總EGCG是114.3±4.1和

    116.4±4.1 NMH,分別為(平均值±標準差,n= 3-5)。為了盡量減少潛在的體外等離子體降解,

    一種新的穩定的20mM抗壞血酸(AA)的溶液和13 mM的三[[2 - 羧乙基膦

    鹽酸鹽(TCEP)。比較評價的20mM AA的療效和

    13 mM的TCEP穩定溶液常用的穩定溶液的114 mM的AA和

    0.13毫摩爾乙二胺四乙酸二鈉,表明的AA/ TCEP溶液提供了顯著更大的(P <0.05)的保護

    EGCG比AA/Na2EDTA穩定的解決方案。總體而言,這項研究表明,血藥濃度

    表沒食子兒茶素沒食子酸酯是反映的劑量給小鼠口服給藥後在低nM範圍的

    消耗一個標準綠茶飲料。此外,一種新的穩定的解決方案已被確定

    這可能是有用的藥代動力學研究得到穩定的血漿樣本。

    參考資料: 網路
還有問題?馬上發問,尋求解答。