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qreen 發問時間: 社會與文化語言 · 7 年前

<急>誰可以幫我翻paper??送20點

拜託不要用翻譯機直接翻.謝謝喔~~

Abstract.

Background/Objective:

Patients with posterior cortical atrophy (PCA) often have Alzheimer disease (AD) at autopsy, yet are cognitively and anatomically distinct from patients with clinical AD. We sought to compare the distribution of β-amyloid and glucose metabolism in PCA and AD in vivo using Pittsburgh compound B (PiB) and FDG-PET.

Methods:

Patients with PCA (n = 12, age 57.5 ± 7.4, Mini-Mental State Examination [MMSE] 22.2 ± 5.1), AD (n = 14, age 58.8 ± 9.6, MMSE 23.8 ± 6.7), and cognitively normal controls (NC, n = 30, age 73.6 ± 6.4) underwent PiB and FDG-PET. Group differences in PiB distribution volume ratios (DVR, cerebellar reference) and FDG uptake (pons-averaged) were assessed on a voxel-wise basis and by comparing binding in regions of interest (ROIs).

Results:

Compared to NC, both patients with AD and patients with PCA showed diffuse PiB uptake throughout frontal, temporoparietal, and occipital cortex (p < 0.0001). There were no regional differences in PiB binding between PCA and AD even after correcting for atrophy. FDG patterns in PCA and AD were distinct: while both groups showed hypometabolism compared to NC in temporoparietal cortex and precuneus/posterior cingulate, patients with PCA further showed hypometabolism in inferior occipitotemporal cortex compared to both NC and patients with AD (p < 0.05). Patients with AD did not show areas of relative hypometabolism compared to PCA.

Conclusions:

Fibrillar amyloid deposition in PCA is diffuse and similar to AD, while glucose hypometabolism extends more posteriorly into occipital cortex. Further studies are needed to determine the mechanisms of selective network degeneration in focal variants of AD.

1 個解答

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  • 7 年前
    最佳解答

    摘要

    背景/目標

    腦後部皮組織萎縮(PCA)的病患通常在檢驗時會發現有阿茲海默症(AD),其認知和結構上不同於臨床上的阿茲海默症。我們藉著研究及使用(PiB)和正子電腦斷層,來比較β-澱粉樣蛋白前體和葡萄糖代謝在PCA和AD在活體內如何分布。

    方法

    PCA患者(n = 12, 年齡 57.5 ± 7.4, 簡易智能狀態測驗(MMSE) 22.2 ± 5.1),AD患者(n = 14, 年齡 58.8 ± 9.6, 簡易智能狀態測驗(MMSE) 23.8 ± 6.7),和認知正常控制組(NC組)(n = 30, 年齡 73.6 ± 6.4)),讓這三組經過 PiB 和 正子電腦斷層。發現族群區別在 PiB DVR (小腦)和正子電腦斷層,其判定方式是擴散張量體及比較綁定ROIs

    結果

    比較NC和AD患者、PCA患者,顯示PiB散佈前葉、活性和腦皮層(p < 0.0001)。甚至在經過矯正萎縮後,在PCA和AD患者也沒有明顯局部差別。PCA和AD在FDG顯現上有特別的地方:與NC組比較腦皮層活性、楔前葉、後扣帶皮層,PCA和AD組均顯示基礎代謝率減退,PCA患者與C和AD患者比較後,顯示在更下的後枕顳腦皮層出現基礎代謝率減退(p < 0.05)。對照PCA患者,AD患者並未顯示有任何基礎代謝率減退的區域。

    結論

    纖維乙型類澱粉蛋白分布在PCA和AD患者相似,當葡萄糖基礎代謝率減退存在於

    更多氣候的腦皮層。接下來的研究AD的重點,在於決定有選擇性的退化網狀系統機械設備。

    參考資料: ME (很多醫學專有名詞,有試著找出來,如有誤煩請自行更正^^”)
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