LULU 發問時間: 社會與文化語言 · 8 年前

請幫忙翻譯這段關於基因轉殖的英文(英翻中)

• What percentage of subjects will manifest transaminitis and loss of FIX expression at the top dose?

• Can optimization with a gain-of-function mutation reduce the vector dose, thereby reducing immune-mediated transaminitis (FIX Padua variant R338L)?

• What percentage of these will respond to prednisolone?

• What are the treatment strategies for those with pre-existing antibodies to AAV8? Are there other serotypes available for those with pre-existing immunity and for top-up doses of gene therapy for those with loss of expression with time? In case of cross reactivity, compartmentalized delivery may yield robust expression .

Or variants of serotypes obtained by introducing specific mutations in the capsid may reduce cross reactivity .

4 個解答

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  • 晚風
    Lv 5
    8 年前
    最佳解答

    • What percentage of subjectswill manifest transaminitis and loss of FIX expression at the top dose? 多少百分比的受測者在最高劑量下會顯現轉氨脢升高跟凝血因子表現衰退?

    • Can optimization with a gain-of-function mutation reduce the vector dose,thereby reducing immune-mediated transaminitis (FIX Padua variant R338L)? 功能獲得性突變的最佳化能夠降低假體劑量,因而減少抵抗力媒介型(或稱免疫型)轉氨酶炎嗎(凝血因子Padua變體R338L)?

    • What percentage of these will respond to prednisolone? 這些受測者有多少百分比對抗炎敏有所反應?

    • What are the treatment strategies for those with pre-existing antibodies toAAV8? Are there other serotypes available for those with pre-existing immunityand for top-up doses of gene therapy for those with loss of expression withtime? In case of cross reactivity, compartmentalized delivery may yield robustexpression. 對於那些原本就帶有腺病毒載體8型抗體的人有何醫療策略?有沒有那些具既有免疫力的人以及表現隨著時間衰退者基因療法的半生物效應劑量可用的其他血清型呢?若是出現交叉反應,分類傳送可能產生穩健的表現。 Or variants of serotypesobtained by introducing specific mutations in the capsid may reduce crossreactivity. 或者,藉由衣殼內特定抗體的導入所獲得的血清變體可能減少交叉反應。 轉氨酶炎(transaminitis,無症狀的血清轉氨酶升高)prednisolone (抗炎敏):一種皮質性類固醇,作用為緩解發炎反應(腫、熱、紅、痛)。

    參考資料: Nightwind
  • 8 年前

    What percentage of subjects will manifest transaminitis and loss of FIX expression at the top dose?

    將清單轉氨酶和損失FIX表達在頂部的劑量有多少百分比的科目?

    Can optimization with a gain-of-function mutation reduce the vector dose, thereby reducing immune-mediated transaminitis (FIX Padua variant R338L)?

    優化與增益功能突變可以降低矢量劑量,從而減少免疫介導的轉氨酶(FIX帕多瓦變種R338L)?

    • What percentage of these will respond to prednisolone?

    •這些百分比將回應強的松嗎?

    What are the treatment strategies for those with pre-existing antibodies to AAV8? Are there other serotypes available for those with pre-existing immunity and for top-up doses of gene therapy for those with loss of expression with time? In case of cross reactivity, compartmentalized delivery may yield robust expression .

    • 對於那些與預先存在的抗體AAV8治療策略是什麼?是否有其他血清型,可對於那些與預先存在的免疫力和補足虧損的表達隨著時間的推移,那些基因治療的劑量?交貨條塊交叉反應的情況下,可能會產生強大的表達。

    Or variants of serotypes obtained by introducing specific mutations in the capsid may reduce cross reactivity .

    或其變體的血清型的衣殼中引入特定的突變通過以下方式獲得可減少交叉反應。

  • 8 年前

    •什麼科目比例將FIX表達的頂部劑量清單轉氨酶和損失?

    •優化與增益功能突變可以降低矢量劑量,從而減少免疫介導的轉氨酶(FIX帕多瓦變種R338L)?

    •這些百分比將回應強的松嗎?

    AAV8與預先存在的抗體治療策略是什麼?是否有其他血清型,可對於那些與預先存在的免疫力和補足虧損的表達隨著時間的推移,那些基因治療的劑量?交貨條塊交叉反應的情況下,可能會產生強大的表達。

    或其變體的血清型的衣殼中引入特定的突變通過以下方式獲得可減少交叉反應。

  • 蕙安
    Lv 5
    8 年前

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