請英文高手幫忙翻譯一下

Several cellular mechanisms were suggested for cocaine-induced cytotoxicity in PC12 cells. It was shown that cocaine might produce selective toxic effects which are related to the induction of apoptosis such as activation of caspase, decreased mitochondrial cytochrome c content, activation of transcription nuclear... 顯示更多 Several cellular mechanisms were suggested for cocaine-induced cytotoxicity in PC12 cells. It was shown that cocaine might produce selective toxic effects which are related to the induction of apoptosis such as activation of caspase, decreased mitochondrial cytochrome c content, activation of transcription nuclear factor kappa-b and cytokine involvement. In addition, drugs of abuse have been shown to induce death of cultured PC12 cells which can be associated with an increase in dopamine turnover and oxidative cell injury. Recently, it was shown that human neuronal progenitor cells treatedwith cocaine demonstrated enlargement of cell death associated with increased markers of oxidative stress. These findings indicate that cocaine-induced oxidative damage may promote cell death, therefore exogenous antioxidant strategies may be useful in the treatment and prevention of this disorder. In order to examine antioxidant protective effects in cocaineinduced cytotoxicity associated with oxidative damage progression, we used the well established PC12 cell line as an in vitro model. We demonstrated that PC12 cells exposed to high concentrations of cocaine (1–4 mM) exhibited a significant decline of cell viability as demonstrated previously. Although cocaine physiological effects were elicited in a micromolar concentration, high concentrations were used in this study to enhance rapid cell death which can mimic the effect of chronic cocaine exposure on cell and organelle damage that results in an increased cell death. In addition to the findings that cocaine induced cell death, it was also shown that PC12 cells when exposed to cocaine exhibited amplification of oxidative stress markers such as mitochondrial superoxide radicals and peroxides.

本人用google翻譯發現很多句子都翻得很奇怪 請不要直接把google的翻譯直接貼過來 麻煩幫忙翻一下 謝謝
1 個解答 1